Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
Ahead of Print -Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013 - Volume 21, Number 7—July 2015 - Emerging Infectious Disease journal - CDC
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