During 2014–2015, patients in northeastern Kenya were assessed for brucellosis and characteristics that might help clinicians identify brucellosis. Among 146 confirmed brucellosis patients, 29 (20%) had negative serologic tests. No clinical feature was a good indicator of infection, which was associated with animal contact and drinking raw milk.
Ahead of Print -Human Brucellosis in Febrile Patients Seeking Treatment at Remote Hospitals, Northeastern Kenya, 2014–2015 - Volume 22, Number 12—December 2016 - Emerging Infectious Disease journal - CDC
Thursday, September 22, 2016
Ahead of Print -Upsurge of Enterovirus D68, the Netherlands, 2016 - Volume 23, Number 1—January 2017 - Emerging Infectious Disease journal - CDC
In June and July 2016, we identified 8 adults and 17 children with respiratory enterovirus D68 infections. Thirteen children required intensive care unit admission because of respiratory insufficiency, and 1 had concomitant acute flaccid myelitis. Phylogenetic analysis showed that all of 20 sequences obtained belong to the recently described clade B3.
Ahead of Print -Upsurge of Enterovirus D68, the Netherlands, 2016 - Volume 23, Number 1—January 2017 - Emerging Infectious Disease journal - CDC
Ahead of Print -Upsurge of Enterovirus D68, the Netherlands, 2016 - Volume 23, Number 1—January 2017 - Emerging Infectious Disease journal - CDC
Chan Zuckerberg Initiative will invest $3 billion to cure disease - Sep. 21, 2016
Pediatrician Dr. Priscilla Chan and her husband Facebook CEO Mark Zuckerberg are investing billions in making the world healthier.
In an emotional announcement in San Francisco on Wednesday, Chan said the Chan Zuckerberg Initiative will be investing $3 billion over 10 years to build tools to advance health care.
Chan Zuckerberg Initiative will invest $3 billion to cure disease - Sep. 21, 2016
In an emotional announcement in San Francisco on Wednesday, Chan said the Chan Zuckerberg Initiative will be investing $3 billion over 10 years to build tools to advance health care.
Chan Zuckerberg Initiative will invest $3 billion to cure disease - Sep. 21, 2016
Friday, September 16, 2016
Wednesday, September 14, 2016
Tempers flare as public protests spraying for Zika mosquitoes in South Beach | Miami Herald
A contentious debate over aerial insecticide spraying to knock down mosquitoes carrying Zika virus raged again Wednesday morning in Miami Beach.
Tempers flare as public protests spraying for Zika mosquitoes in South Beach | Miami Herald
Tempers flare as public protests spraying for Zika mosquitoes in South Beach | Miami Herald
Ahead of Print -Outbreaks of Human Salmonella Infections Associated with Live Poultry, United States, 1990–2014 - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Backyard poultry flocks have increased in popularity concurrent with an increase in live poultry–associated salmonellosis (LPAS) outbreaks. Better understanding of practices that contribute to this emerging public health issue is needed. We reviewed outbreak reports to describe the epidemiology of LPAS outbreaks in the United States, examine changes in trends, and inform prevention campaigns. LPAS outbreaks were defined as ≥2 culture-confirmed human Salmonella infections linked to live poultry contact. Outbreak data were obtained through multiple databases and a literature review. During 1990–2014, a total of 53 LPAS outbreaks were documented, involving 2,630 illnesses, 387 hospitalizations, and 5 deaths. Median patient age was 9 years (range <1 to 92 years). Chick and duckling exposure were reported by 85% and 38% of case-patients, respectively. High-risk practices included keeping poultry inside households (46% of case-patients) and kissing birds (13%). Comprehensive One Health strategies are needed to prevent illnesses associated with live poultry.
Ahead of Print -Outbreaks of Human Salmonella Infections Associated with Live Poultry, United States, 1990–2014 - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Ahead of Print -Outbreaks of Human Salmonella Infections Associated with Live Poultry, United States, 1990–2014 - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Ahead of Print -Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Carbapenems have been used for many years to treat severe nosocomial Enterobacteriaceae infections. The spread of resistance to these drugs among other bacterial families is an emerging problem worldwide, mostly caused by New Delhi metallo-β-lactamase (NDM-1). We screened for the prevalence of NDM-1–expressing enteric pathogens from hospitalized patients with acute diarrhea in Kolkata, India, and identified 27 Vibrio fluvialis–harboring blaNDM-1 (NDM-VF) strains. These isolates were also resistant to all the tested antimicrobial drugs except doxycycline. The large plasmid of V. fluvialis harboring blaNDM-1 could be easily transferred to other enteric pathogens. Genes flanking the blaNDM-1 were found to be identical to the reported sequence from an Escherichia coli isolate. Analyses showed that the V. fluvialis possessing the NDM-VF region belonged to different clones. The pathogenicity of V. fluvialis to humans and its ubiquitous presence in the environment call for constant monitoring of this species for emerging antimicrobial drug resistance.
Ahead of Print -Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Ahead of Print -Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Ahead of Print -Effect of Geography on the Analysis of Coccidioidomycosis-Associated Deaths, United States - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Because coccidioidomycosis death rates vary by region, we reanalyzed coccidioidomycosis-associated mortality in the United States by race/ethnicity, then limited analysis to Arizona and California. Coccidioidomycosis-associated deaths were shown to increase among African-Americans but decrease among Native Americans and Hispanics. Separately, in a Native American cohort, diabetes co-varied with coccidioidomycosis-associated death.
Ahead of Print -Effect of Geography on the Analysis of Coccidioidomycosis-Associated Deaths, United States - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Ahead of Print -Effect of Geography on the Analysis of Coccidioidomycosis-Associated Deaths, United States - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Ahead of Print -Cat-Scratch Disease in the United States, 2005–2013 - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Cat-scratch disease (CSD) is mostly preventable. More information about the epidemiology and extent of CSD would help direct prevention efforts to those at highest risk. To gain such information, we reviewed the 2005–2013 MarketScan national health insurance claims databases and identified patients <65 years of age with an inpatient admission or outpatient visit that included a CSD code from the International Classification of Diseases, Ninth Revision, Clinical Modification. Incidence of CSD was highest among those who lived in the southern United States (6.4 cases/100,000 population) and among children 5–9 years of age (9.4 cases/100,000 population). Inpatients were significantly more likely than outpatients to be male and 50–64 years of age. We estimate that each year, 12,000 outpatients are given a CSD diagnosis and 500 inpatients are hospitalized for CSD. Prevention measures (e.g., flea control for cats) are particularly helpful in southern states and in households with children.
Ahead of Print -Cat-Scratch Disease in the United States, 2005–2013 - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Ahead of Print -Cat-Scratch Disease in the United States, 2005–2013 - Volume 22, Number 10—October 2016 - Emerging Infectious Disease journal - CDC
Friday, September 2, 2016
Ahead of Print -Whole-Genome Characterization and Strain Comparison of VT2f-Producing Escherichia coli Causing Hemolytic Uremic Syndrome - Volume 22, Number 12—December 2016 - Emerging Infectious Disease journal - CDC
Verotoxigenic Escherichia coli infections in humans cause disease ranging from uncomplicated intestinal illnesses to bloody diarrhea and systemic sequelae, such as hemolytic uremic syndrome (HUS). Previous research indicated that pigeons may be a reservoir for a population of verotoxigenic E. coli producing the VT2f variant. We used whole-genome sequencing to characterize a set of VT2f-producing E. coli strains from human patients with diarrhea or HUS and from healthy pigeons. We describe a phage conveying thevtx2f genes and provide evidence that the strains causing milder diarrheal disease may be transmitted to humans from pigeons. The strains causing HUS could derive from VT2f phage acquisition by E. coli strains with a virulence genes asset resembling that of typical HUS-associated verotoxigenic E. coli.
Ahead of Print -Whole-Genome Characterization and Strain Comparison of VT2f-Producing Escherichia coli Causing Hemolytic Uremic Syndrome - Volume 22, Number 12—December 2016 - Emerging Infectious Disease journal - CDC
Ahead of Print -Whole-Genome Characterization and Strain Comparison of VT2f-Producing Escherichia coli Causing Hemolytic Uremic Syndrome - Volume 22, Number 12—December 2016 - Emerging Infectious Disease journal - CDC
Thursday, September 1, 2016
Strawberries linked to hepatitis A outbreak in 6 states
Strawberries linked to hepatitis A outbreak in 6 states: An outbreak of hepatitis A caused by imported frozen strawberries from Egypt has sickened 55 people in six states, the US Centers for Disease Control and Prevention said Wednesday. Health...
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