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Drug resistance deadlier than cancer by 2050: Study

Infections resistant to medicines will kill more people per year than cancer by 2050, and cost the world $100 trillion annually, according to a U.K. government-backed report led by Jim O'Neill, the well-known former Goldman Sachs economist.

http://www.cnbc.com/2014/12/11/drug-resistance-to-kill-more-than-cancer-by-2050-study.html?__source=facebook%7Chealthcare%7Clink%7C122615%7C10PM%7Cdeadlier-than-cancer

Ahead of Print -Nanopore Sequencing as a Rapidly Deployable Ebola Outbreak Tool - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

Rapid sequencing of RNA/DNA from pathogen samples obtained during disease outbreaks provides critical scientific and public health information. However, challenges exist for exporting samples to laboratories or establishing conventional sequencers in remote outbreak regions. We successfully used a novel, pocket-sized nanopore sequencer at a field diagnostic laboratory in Liberia during the current Ebola virus outbreak.



Ahead of Print -Nanopore Sequencing as a Rapidly Deployable Ebola Outbreak Tool - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

Ahead of Print -Hospital Preparations for Viral Hemorrhagic Fever Patients and Experience Gained from Admission of an Ebola Patient - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

The Major Incident Hospital of the University Medical Centre of Utrecht has a longstanding history of preparing for the management of highly pathogenic and infectious organisms. An assessment of the hospital’s preparations for an outbreak of viral hemorrhagic fever and its experience during admission of a patient with Ebola virus disease showed that the use of the buddy system, frequent training, and information sessions for staff and their relatives greatly increased the sense of safety and motivation among staff. Differing procedures among ambulance services limited the number of services used for transporting patients. Waste management was the greatest concern, and destruction of waste had to be outsourced. The admission of an Ebola patient proceeded without incident but led to considerable demands on staff. The maximum time allowed for wearing personal protective equipment was 45 minutes to ensure safety, and an additional 20 minutes was needed for recovery.



Ahead of Print -Hospital Preparations for Viral Hemorrhagic Fever Patients and Experience Gained from Admission of an Ebola Patient - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

Ahead of Print -Association between Landscape Factors and Spatial Patterns of Plasmodium knowlesi Infections in Sabah, Malaysia - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

The zoonotic malaria species Plasmodium knowlesi has become the main cause of human malaria in Malaysian Borneo. Deforestation and associated environmental and population changes have been hypothesized as main drivers of this apparent emergence. We gathered village-level data for P. knowlesiincidence for the districts of Kudat and Kota Marudu in Sabah state, Malaysia, for 2008–2012. We adjusted malaria records from routine reporting systems to reflect the diagnostic uncertainty of microscopy for P. knowlesi. We also developed negative binomial spatial autoregressive models to assess potential associations between P. knowlesi incidence and environmental variables derived from satellite-based remote-sensing data. Marked spatial heterogeneity in P. knowlesi incidence was observed, and village-level numbers of P. knowlesi cases were positively associated with forest cover and historical forest loss in surrounding areas. These results suggest the likelihood that deforestation and associated environmental changes are key drivers in P. knowlesi transmission in these areas.



Ahead of Print -Association between Landscape Factors and Spatial Patterns of Plasmodium knowlesi Infections in Sabah, Malaysia - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

Ahead of Print -Prognostic Indicators for Ebola Patient Survival - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus–positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus–positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations.



Ahead of Print -Prognostic Indicators for Ebola Patient Survival - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

Ahead of Print -Identification of Source of Brucella suis Infection in Human by Whole-Genome Sequencing, United States and Tonga - Volume 22, Number 1—January 2016 - Emerging Infectious Disease journal - CDC

Brucella suis infection was diagnosed in a man from Tonga, Polynesia, who had butchered swine in Oregon, USA. Although the US commercial swine herd is designated brucellosis-free, exposure history suggested infection from commercial pigs. We used whole-genome sequencing to determine that the man was infected in Tonga, averting a field investigation.



Ahead of Print -Identification of Source of Brucella suis Infection in Human by Whole-Genome Sequencing, United States and Tonga - Volume 22, Number 1—January 2016 - Emerging Infectious Disease journal - CDC

Ahead of Print -Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient - Volume 22, Number 1—January 2016 - Emerging Infectious Disease journal - CDC

WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient’s lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.



Ahead of Print -Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient - Volume 22, Number 1—January 2016 - Emerging Infectious Disease journal - CDC

Meningococcal disease survivor shares life-saving message | Fox News

Jamie Schanbaum was a 20-year-old student at the University of Texas when she fell sick with pain all over her body. She wasn’t able to walk, and couldn’t retain any heat.



Meningococcal disease survivor shares life-saving message | Fox News

Ahead of Print -The Merits of Malaria Diagnostics during an Ebola Virus Disease Outbreak - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

Malaria is a major public health concern in the countries affected by the Ebola virus disease epidemic in West Africa. We determined the feasibility of using molecular malaria diagnostics during an Ebola virus disease outbreak and report the incidence of Plasmodium spp. parasitemia in persons with suspected Ebola virus infection.



Ahead of Print -The Merits of Malaria Diagnostics during an Ebola Virus Disease Outbreak - Volume 22, Number 2—February 2016 - Emerging Infectious Disease journal - CDC

Ahead of Print -Surveillance of Bacterial Meningitis, Ethiopia, 2012–2013 - Volume 22, Number 1—January 2016 - Emerging Infectious Disease journal - CDC

Among 139 patients with suspected bacterial meningitis in Ethiopia, 2012–2013, meningococci (19.4%) and pneumococci (12.9%) were the major disease-causing organisms. Meningococcal serogroups detected were A (n = 11), W (n = 7), C (n = 1), and X (n = 1). Affordable, multivalent meningitis vaccines for the African meningitis belt are urgently needed.



Ahead of Print -Surveillance of Bacterial Meningitis, Ethiopia, 2012–2013 - Volume 22, Number 1—January 2016 - Emerging Infectious Disease journal - CDC

Ahead of Print -Rift Valley Fever Virus among Wild Ruminants, Etosha National Park, Namibia, 2011 - Volume 22, Number 1—January 2016 - Emerging Infectious Disease journal - CDC

After a May 2011 outbreak of Rift Valley fever among livestock northeast of Etosha National Park, Namibia, wild ruminants in the park were tested for the virus. Antibodies were detected in springbok, wildebeest, and black-faced impala, and viral RNA was detected in springbok. Seroprevalence was high, and immune response was long lasting.



Ahead of Print -Rift Valley Fever Virus among Wild Ruminants, Etosha National Park, Namibia, 2011 - Volume 22, Number 1—January 2016 - Emerging Infectious Disease journal - CDC

CDC says disease rates on the rise | fox4kc.com

In the past year, the rates of people with sexually transmitted diseases in the U.S. have increased dramatically, according to the most recent 2014 report from the Centers for Disease Control and Prevention (CDC). Despite having been on the decline for years, the number of cases of chlamydia and gonorrhea rose from 2013 to 2014, and cases of syphilis rose by 15.1% year over year.

Though these increases are troubling, they aren’t the only disease rates that have seen growth in the last couple of years. Using data from the CDC, HealthGrove identified 14 diseases that have risen in the U.S. in the past decade.

CDC says disease rates on the rise | fox4kc.com